Haematology has lost a giant: Paul Sylvain Frenette died in July, aged 56. His research led directly to the development of therapies that changed clinical practice. And he taught us — his former trainees — by example and shaped our careers.
Frenette was the inaugural director of the Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine at Albert Einstein College of Medicine in New York City, where he built one of the strongest interdisciplinary stem-cell programmes in the United States. He developed new paradigms across a range of haematology topics.
For example, he helped to discover the mechanisms mediating vaso-occlusion in sickle-cell disease (A. Turhan et al. Proc. Natl Acad. Sci. USA 99, 3047–3051; 2002); to define how the nervous system regulates haematopoiesis (Y. Katayama et al. Cell 124, 407–421; 2006); and to identify fundamental components and mechanisms through which the bone marrow niche regulates haematopoietic stem cells (see, for example, S. Méndez-Ferrer et al. Nature 466, 829–834; 2010).
As a stellar academic, Frenette trained and influenced many scientists. He encouraged us to identify the key significance of our hypotheses and to do the best experiments to prove them.
Nature 597, 31 (2021)
The authors declare no competing interests.