Nature

Protein architecture of the yeast genome

RESEARCH SUMMARY

Protein architecture of the yeast genome

Use of chromatin immunoprecipitation with exonuclease treatment (ChIP–exo) determines the positional organization of hundreds of chromosomal proteins throughout the Saccharomyces cerevisiae genome. The resulting ultra-high-resolution map provides insight into the regulation of genes, enhancers, replication origins, centromeres, subtelomeres and transposons.

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Competing Interests

B.F.P. has a financial interest in Peconic, LLC, which offers the ChIP–exo technology (US Patent 20100323361A1) implemented herein as a commercial service and could potentially benefit from the outcomes of this research.

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